Meanwhile, Hutterite children have an unusually high prevalence of asthma -- 21.3 percent -- said the study.
"Over a decade ago, our colleague Erika von Mutius discovered that growing up on a farm can protect against asthma," said study co-author Carole Ober, professor and chairman of human genetics at the University of Chicago.
"Our new study, building on her work, now shows that it's not simply farming, and has narrowed in on what the specific protection might be."
- 'Richer' home dust -
Researchers found that the difference came down to the kind of dust inside their homes.
Dust in Amish homes was "much richer in microbial products," said the study.
"Neither the Amish nor the Hutterites have dirty homes," explained Ober.
"Both are tidy. The Amish barns, however, are much closer to their homes. Their children run in and out of them, often barefoot, all day long. There's no obvious dirt in the Amish homes, no lapse of cleanliness. It's just in the air, and in the dust."
This dust engages the children's innate immune system to fight off asthma, the study found.
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Blood tests done on 30 Amish children -- aged seven to 14 -- and 30 Hutterite children of the same age range showed the Amish had more blood cells crucial to fighting infections, known as neutrophils.
The Amish also had fewer blood cells that promote allergic inflammation, known as eosinophils.
When researchers exposed lab mice to the Amish house dust, they found the rodents were protected against asthma-like responses to allergens. Similar experiments with the Hutterite house dust conveyed no protection.
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According to Sherry Farzan, a doctor in the department of medicine and pediatrics, allergy and immunology at Northwell Health in New York, the paper offers more evidence to back up what has been called the "hygiene hypothesis," which suggests that a lack of early microbial exposure increases the risk of allergy.
"Exposure to a rich microbiome early in life is protective of allergy and asthma, and seems to be due to the anti-inflammatory modulatory activity of this exposure," said Farzan, who was not involved in the study.
For co-author Erika von Mutius, professor at the Dr. von Hauner Children's Hospital in Munich, Germany, the next step is to find a way to apply this knowledge to help future generations of children.
"We hope that our findings will allow the identification of relevant substances that will lead to completely novel strategies to prevent asthma and allergy," she said.