We've been conjecturing about life on Mars for centuries. In popular culture, the concept of intelligent life on Mars was championed by astronomer Percival Lowell in the late 1800s and his theories on the Martian canals. Science fiction writers -- always game for some reckless conjecture -- took up the banner from there.
Perhaps the most famous Martians in the history of sci-fi and popular culture, the invaders in H.G. Wells' 1898 novel "War of the Worlds," have since spawned dozens of films, TV shows, comic books and one very famous radio drama.