A superbug resistant to all known medications has been found in the United States for the first time, raising new concern about the dwindling effectiveness of antibiotics, the top US public health official said on Thursday.
The case involved a 49-year-old woman in Pennsylvania whose urinary tract infection tested positive for a strain of E. coli that is resistant to the antibiotic of last resort for such infections, known as colistin.
"It was an old antibiotic, but it was the only one left for what I call nightmare bacteria," a family of germs known as carbapenem-resistant Enterobacteriaceae (CRE), said Thomas Frieden, chief of the US Centers for Disease Control and Prevention.
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The recently discovered antibiotic-resistant gene, known as mcr-1, has also been found in China and Europe.
Its emergence in the United States for the first time "heralds the emergence of truly pan-drug resistant bacteria," said a report on the finding, published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.
The report gave no details about the outcome of the Pennsylvania woman's case. Superbugs can be deadly, but not in all cases.
The woman had not traveled outside the United States, so could not have acquired the resistant bacteria elsewhere, Frieden said.
"We know now that the more we look, the more we are going to find," he added. "We risk being in a post-antibiotic world."
Colistin has been available since 1959 to treat infections caused by E. coli, Salmonella, and Acinetobacter, which can cause pneumonia or serious blood and wound infections.
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