Moissidou and colleagues at the University of Madrid and Athens presented their research at the recent International Conference of Comparative Mummy Studies in Hildesheim, Germany.
The mummified head, which currently belongs to the Museo de Antropología Médica, Forense, Paleopatología y Criminalística in Madrid, Spain, was first described as the "beheaded head of a Guinean negress young woman."
The head's true origins were found only in 2007, when Moissidou and colleagues traced the mummified remains back to the Theban Necropolis archaeological area in Egypt. The head's mummification technique made it possible to date it to the 18th Dynasty of the New Kingdom.
This is the best known ancient Egyptian dynasty as it includes several famous pharaohs, such as Hatshepsut, Amenhotep III, Akhenaten and Tutankhamun. The researchers believe the woman lived in a period between the reign of Thutmose II and Thutmose III.
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The head's whereabouts are still a mystery. Its recorded history begins sometime between 1898-1930, when it appears in the Cairo Museum. The head was then sold to the Spanish collector and banker Ignacio Bauer and finally donated to the Real Sociedad de Arqueología, Antropologíay Prehistoria in Madrid.
"Looking at the accurate embalming, we can say this lady was an important member of the Egyptian society of the time," Gonzalez said.
Moissidou and colleagues carried out several examinations to confirm the diagnosis of exogenous ochronosis.
"Samples were retrieved from the base of the neck and were sent for histological examination," Moissidou said.
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The primary results showed a chronic skin inflammation, while chemistry confirmed it. Electron microscopy revealed striking similarities with contemporary tissue affected by exogenous ochronosis.
"We know the ancient Egyptians regarded the use of cosmetics both for aesthetic purposes as well as magical and religious ones. Cosmetic pigments were indeed used on a daily basis," Moissidou said.
But many of the cosmetics used by the Egyptians included lead as a basic component, which could cause skin inflammation as well as skin diseases.
Intriguingly, the use of such cosmetics was common among members of royal families.
"This opens up new interesting questions on the head's identity. Further research is now needed," Moissidou said.