Two firefighters were lightly injured after being surrounded by flames. They were treated at a hospital and released, and were back on the line fighting the blaze, Inciweb said.
The wildfire poses "imminent threat to public safety, rail traffic and structures," according to the website, which said 82,640 people fell under an evacuation warning.
Several area roads were closed, as was the Mountain High ski resort in Wrightwood which hosts hiking and other outdoor activities in warmer months.
California is in its fifth year of a record drought and parts of the state are sizzling in a heatwave with temperatures topping 104 degrees Fahrenheit.
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Strong seasonal gusts known as the Santa Ana winds complete the perfect conditions for wildfires.
Another major fire has been burning 100 miles north of San Francisco since Saturday.
The Clayton fire, as it is called, has burned more than 4,000 acres and is being fought by around 1,700 fire personnel who have brought 35 percent of the blaze under control, according to Cal Fire.
More than 175 buildings have been destroyed as the blaze continues to move aggressively to the north, it said.
In central California's wine region, the Chimney fire burned 6,900 acres near the city of San Luis Obispo. It destroyed 40 buildings since starting on Saturday, and was only 20 percent contained.
And in the scenic coastal area of Big Sur, the Soberanes fire had scorched more than 76,000 acres and was 60 percent contained.
Twenty major fires are currently raging across the western United States. There were six in California, four in Wyoming and three each in Colorado and Montana, according to the National Interagency Fire Center.