Giant Rats Sniff Out TB in Mozambique

Giant rats may strike fear and disgust into the hearts of homeowners worldwide, but researchers in impoverished Mozambique are improbably turning some of them into heroes.

At Eduardo Mondlane University in the capital Maputo, nine giant rats are busy at work -- sniffing out tuberculosis-causing bacteria from rows of sputum samples.

These are no ordinary rats, as they have undergone six months of training in Tanzania. Their most distinguishing asset is their impeccable sense of smell.

Placed inside a glass cage, a rat darts from sample to sample, then stops or rubs its legs, indicating that a sample is infected with a TB causing bacteria.

Once the task is complete, it is given a treat through a syringe for a job well done.

"Within 30 minutes, the rat can test close to a hundred samples, which normally takes a laboratory technician four days," said Emilio Valverde, TB program director at APOPO, the organisation leading the research.

The project, which started in February 2013, has brought hope to thousands of TB sufferers who sometimes receive false results and test negative using the standard laboratory system.

In 2006, tuberculosis was declared a national emergency in Mozambique, with 60,000 people in 2014 said to be infected, according to the ministry of health.

That number was a 10 percent increase from 2013.

Samples delivered to the university for testing are collected from 15 health centres across Maputo.

Belgian group APOPO is planning to expand the program to other parts of the country, while working on getting the system approved by the World Health Organization.

The organisation claims rat testing is more cost effective than other conventional methods.

Each rat costs around $6,700 to $8,000 to train, with a six-to-eight-year life span.

The cost is lower compared to rapid diagnostic test GeneXpert, which costs up to $17,000 per device, setting the state back between $10 and $17 per test.

The kitten-size rats are also used by APOPO to detect landmines by sniffing out explosives.

They are light enough to cross terrain without triggering the mines, and are followed by de-mining experts who reward the rats with bananas.

The rats weigh up to 1.5 pounds and are said to be "easier to catch and train" -- according to Valverde.

Samples pointed out by the rats to contain TB bacteria are then sent for further tests using fluorescence microscopy, a more sensitive laboratory technique.

The results are sent back to health centres, allowing patients to start treatment early.

Although TB is a treatable disease, in underdeveloped countries like Mozambique it can be deadly if left untreated and is particularly harmful to people living with HIV.

Mozambique is one of the countries worst affected by TB and 1 in 10 adults is HIV-positive.

With World Tuberculosis Day being marked on Tuesday, the Mozambican Ministry of Health said it was cautiously monitoring the APOPO work.

"This technique has to be compared to others that are available and already WHO approved, such as GeneXpert or LED microscope," said Ivan Manhica, who heads the national programme for tuberculosis at the health ministry.

According to the WHO, TB killed 1.5 million people in 2013.

January 11, 2011 - They are elusive. They squeal. And they eat almost anything, even each other. And because of all of that, public health officials have not developed any reliable way to curtail the rising population of rats. Add to that budget cuts and cities like New York City, become inundated with the rodents. Frustrated subway workers are drawing attention to their workplace rat problem by offering a free MetroCard to whoever snaps the picture of the nastiest rat in the subway. TWU Local 100, the Transport Workers Union, launched the site, Rat Free Subways in October, 2011, according to Jim Gannon, the union's director of communications.

"There were fewer refuse pickups and the garbage was piling up in some stations," Gannon said. "And if you have a food source, you have rats." The Jamaica Center - Parsons/Archer subway station in Queens, New York has had an ongoing problem with rats, Gannon said. This rat above is feasting on some trash at the station.

Besides getting signatures for a petition to the Metropolitan Transportation Authority (MTA) to adopt a system-wide "rat eradication initiative," the site offers riders a place to "feel some kind of ownership," Gannon said.

The Rat Free Subways site also offers a share your "Rat Tale" section for subway riders to vent about their face to face rodent encounters. "Aggressive rats are bolder about coming onto the platforms, and have even been known to bite riders," according to the web site.

This photo of a giant rat, was reportedly taken after it was discovered at a Foot Locker in the Bronx. Another huge rat was reportedly stabbed with a pitchfork in Brooklyn last year. That one was believed to be a Gambian pouched rat and may have once been a pet or descended from a pet.

The subway workers efforts have paid off for the Parsons/Archer stop. The MTA added trash pickups for the spot, Gannon said. "There are health issues for the workers and for riders," Gannon said. "The subway transit is everywhere in the city. And if you have an exploding population of rats down there. They are going to come up and be everywhere." The Rat Free Subways contest ends January 15. Rats Help Their Friends Get Free