Zhang and his team are expected to describe their method at the American Society for Reproductive Medicine meeting in Salt Lake City, Utah, next month.
An abstract describing the research has been published in the journal Fertility and Sterility, but outside experts said much more remains to be understood about the research.
"As this technology is controversial and a world first, I think the investigators should have submitted a manuscript for full peer review instead of announcing these outcomes in this manner," said Justin St John, professor and Director of the Centre for Genetic Diseases at Monash University.
Attempts began in the 1990s to create a baby by injecting mitochondrial DNA from a donor into the mother's egg, and adding sperm from her partner.
"Some of the babies went on to develop genetic disorders, and the technique was banned," said the New Scientist report.
"The problem may have arisen from the babies having mitochondria from two sources."
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Another outside expert, David Clancy, a lecturer at Lancaster University, recalled that experiments in monkeys have shown that maternal mitochondrial DNA can expand from low levels to significantly higher levels, "which would allow disease to again be transmitted, so we must expect the possibility in humans."
For now, Zhang and his team said the boy's mitochondria has been tested and "they found that less than 1 percent carry the mutation," said the report.
"Hopefully, this is too low to cause any problems; generally it is thought to take around 18 per cent of mitochondria to be affected before problems start."
In addition, his being a boy ensures that he could not pass down any inherited mitochondrial DNA.
"While we should remain vigilant about this technique as new information and research accumulates, let us hope this child grows up and has a long healthy life," said Clancy.