An EgyptAir flight lost early Thursday over the eastern Mediterranean with 66 people on board fell 22,000 feet and swerved sharply in Egyptian airspace before it disappeared from radar screens, Greece's defense minister said.
"The plane carried out a 90-degree turn to the left and a 360-degree turn to the right, falling from 37,000 to 15,000 feet and the signal was lost at around 10,000 feet," Panos Kammenos told a news conference.
"It appears the plane is lost. There are no clear results (from the search) so far," he said.
EgyptAir Flight MS804 from Paris to Cairo is believed lost some 130 nautical miles from the island of Karpathos, between Crete and Rhodes.
The pilot had spoken to Greek flight controllers some 25 minutes before the plane vanished from radar and had not reported a problem, the Greek civil aviation agency said.
"The flight controllers contacted the pilot (with the plane) at a height of 37,000 feet (near Athens)... he did not mention a problem," civil aviation chief Constantinos Litzerakos told Antenna TV.
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Litzerakos said the controllers had last spoken to the pilot "around 0005 GMT", some 25 minutes before the plane disappeared from Greek radar.
A civil aviation statement said the pilot "was in a good mood and gave thanks in Greek when authorized to exit the Athens flight information region.
"We tracked the entire process from the plane's entry (into Greek airspace) to its exit, it does not appear to deviate at all from the coordinates we gave," Litzerakos said.
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The Greek defence ministry said it had dispatched two search planes and a frigate to international waters in the area, with additional resources on standby on Karpathos and nearby Crete, including F-16 warplanes and a submarine.
Greece has asked France and other countries for satellite imagery that could provide additional clues, Kammenos said.
Twenty-six foreigners were among the 56 passengers, including 15 French citizens, a Briton and a Canadian, EgyptAir said.
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The company said contact was lost with the flight about 280 kilometres (175 miles) north of the Egyptian coast.
Neither the Greek coastguard nor the navy could confirm reports that a passing ship had seen "a ball of fire in the sky".
The civil aviation chief said if there had been an explosion, any debris would have scattered across a wide distance.
"It was at a height of 37,000 feet, dispersal is quite logical. This is quite an altitude," he told Antenna.

Shown is a file photo of EgyptAir plane seen on the runway at Cairo Airport.

Is this Amelia Earhart's lost plane, the Electra?
A grainy sonar image captured off an uninhabited tropical island in the southwestern Pacific republic of Kiribati might represent the remains of the famous aviator's plane, according to The International Group for Historic Aircraft Recovery (TIGHAR), which has long been investigating Earhart's last, fateful flight.

Earhart was piloting the Electra, a two-engine plane, in a record attempt to fly around the world at the equator, when she vanished on July 2, 1937.

The researchers had already identified a small debris field of objects at a depth of 200 feet in the waters of Nikumaroro island, some 300 miles southeast of Earhart's target destination, Howland Island.
The site features objects that appear consistent with analysis made by TIGHAR forensic imaging specialist Jeff Glickman of a grainy 1937 photograph of Nikumaroro's western shoreline by British Colonial Service officer Eric R. Bevington.

TIGHAR postulates that flood tides lifted the Electra and carried it over the reef edge, leaving behind the landing gear, which was inadvertently photographed by Officer Bevington three months later in October 1937.

A new twist in the search occurred last March when Richard Conroy, a member of TIGHAR's online Amelia Earhart Search Forum, spotted an anomaly in a sonar map posted online.

The anomaly appears to be the same size and shape of the Electra.

The anomaly lines up nicely with the object seen in the 1937 Bevington photo and in Jeff Glickman's analysis of the underwater image of the debris field.