Did a Stroke Kill Leonardo da Vinci?

The strokes may have reduced the artist's motor activity in his last two years.

Leonardo Da Vinci may have suffered from a recurrent stroke that considerably reduced his motor activity in the last two years of his life and eventually caused his death, according to a historic viewpoint published in the June issue of The Lancet Neurology.

The study, carried out by two Italian medical doctors, examined ancient sources to reconstruct Da Vinci's health from 1517 until his death in 1519 aged 67.

"The diary of Louis d'Aragona's journey, written by Antonio de Beatis, tells us that Leonardo had a right hand's paralysis when he was 65 years old," Antonio Perciaccante, at the department of medicine of Gorizia hospital, told Discovery News.

"Nevertheless, the ancient document reports Da Vinci continued to paint, draw, and teach," he added.

The Hunt for Da Vinci's Descendants

Perciaccante and co-author Alessia Coralli, at the department of surgery of Civita Castellana hospital, noted the account indicates that Leonardo suffered from a right hand's paralysis with partial physical, but not cognitive, consequences.

Da Vinci's health must have however deteriorated, following the report of 15th-century painter, architect and writer Giorgio Vasari.

In his 1550 book "Lives of the Artists," Vasari described Leonardo as a sick and bedridden man, unable to stand up without being "supported by the arms of his servants and his friends."

Oldest Handmade Skull Attributed to Leonardo da Vinci

"He was ill for many months," Vasari wrote.

According to Perciaccante and Coralli, something happened that compromized the general autonomy of the Renaissance genius.

"Our hypothesis is that a first stroke caused the hand's paralysis. Other stroke events then followed, deteriorating Da Vinci's health and motor activity," Perciaccante said.

Photos: Da Vinci's Inventions

Da Vinci died in Amboise, France, on May 2, 1519, in the arms of King Francis I of France, according to Vasari. He attributed the death to a "paroxysm."

"The term refers to a sudden attack or increase of symptoms of a disease that often recurs. Thus, it can adequately describe a stroke," Perciaccante said.

According to the researchers, the hypothesis of a recurrent stroke is supported by medical literature.

Da Vinci's ‘Magi' Hides Master's Original Vision: Photos

"It is known that people who survive a stroke have an increased risk to experience a further stroke," Perciaccante said.

He noted that nearly one out of five patients experience a stroke within 90 days of the first attack.

"We do not know whether there were genetic risk factors in Leonardo's family. In this view, it could be interesting the study of his newly identified descendants," Perciaccante said.

Francis I Receives the Last Breaths of Leonardo da Vinci. Detail of Jean-Auguste-Dominique Ingres' painting.

Breathing Device Leonardo da Vinci was famously fascinated with translating nature's inventiveness into human technology. If birds can fly, he wrote, we not us? And likewise, if fish can breathe underwater... This model of an underwater breathing device, a predecessor to scuba gear, is thought to have been designed by da Vinci in the year 1508. It consists of animal skins that would serve as a sack around the swimmer's head, connected by a tube to the surface. The model was built based on drawings in da Vinci's journals.

Flying Machine This pen and ink sketch, circa 1500, is one of da Vinci's more famous designs. Though it was never built, da Vinci's "ornithopter" flying machine is thought by some to have inspired the first helicopter.

Wings Da Vinci produced more than 100 drawings illustrating his theories on flight. For him, as for modern scientists, detailed observation was a frequent starting point. He believed that the best answer to most any problem could be found in nature. This model, consisting of a jointed framework covered in a single layer of cloth and a hang glider, represents a drawing inspired by the wings of a bat. Frank Fehrenbach, a professor of art and art history at Harvard University and da Vinci expert, says the contraption stands out among da Vinci's inventions: "My favorites are Leonardo's hang-glider...because of its poetics of discovery; his scythed chariots because of their wonderful absurdity in warfare; and his self-propelled cart intended as a theater machine."

Walking on Water This model of a water-walking system conceived by da Vinci early in his life is displayed at the Leonardo Museum in Vinci, Italy, where he was born in 1452. In his drawings Leonardo referred to the contraption as "skis with which one can walk on water." "Leonardo's inspirations came from his capacity to assimilate his thought and imagination to functions and processes in nature," says Fehrenbach. "Nature was the master to compete with."

Links and Chains Though many of da Vinci's creations were never built, his ruminations on basic mechanics would serve as a model for gear and pulley systems in machinery for centuries to come. Pictured here are two of the 700 pages of manuscript found in the National Library of Madrid in 1967, having been lost for nearly two centuries. At right are links and chain drivers, much like those on modern bicycles. An escapement, upper left, is used to convert linear motion into rotary motion as a plunger is pushed down. At left center are two simple release mechanisms, like those found today in cranes.

Cannon Da Vinci is also well known for his war machines. Pictured here is a water-powered, gear-driven machine for manufacturing cannon barrels.

Crossbow This page from da Vinci's notebook details his most famous crossbow, including winding mechanism and trigger. Scholars doubt d Vinci or anyone in his day built this crossbow, but similar bows were part of Greek and Roman artillery long before da Vinci's birth.

Tank This cutaway view shows a 20th century model of a tank designed by da Vinci. Constructed of wood on a round base topped by a cone-shaped shell, its guns are evenly spaced, emerging from the base. Shaped to withstand the cannonballs of the day, it has four independent wheels propelled by manpower and may be driven in any direction.

Wagon The lifting device pictured here would use a log as a lever to bring a stone pillar into an upright position. The wagon is turned over with the pillar, then a rope would pull the log back up to lift the wagon and pillar. As with many da Vinci designs, it is unclear whether the device was ever used, or even built. Still, da Vinci was truly in a league of his own as an inventor, says Fehrenbach, with one caveat: "Benjamin Franklin didn't have Leonardo's imaginative mind, but was far more practical."