Silver calls the Midwest region the toughest, saying there's "about a one-in-three chance that the eventual tournament champion will emerge from it, the highest of the four sub-brackets."
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Much of Louisville's advantage has to do with their travel itinerary, which Silver calls their "saving grace." The top-seeded Cardinals' road to the championship begins in Lexington, KY (only 70 miles from campus) and runs through Indianapolis (just over 100 miles) and Atlanta (around 300 miles).
So there you have it, folks, Silver has spoken: Louisville over Indiana, a match up that would surely shake up the Ohio River Valley. My kin hail from north of the Ohio, so despite Silver's predictions, I'm banking on the Hoosiers bringing the title back home to Bloomington.
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