More than 180 patients may have been exposed to the drug-resistant superbug called CRE at UCLA’s Ronald Reagan Medical Center, reported theLos Angeles Times
. Two patients have died. The hospital is notifying patients who were exposed to a medical scope that's difficult to disinfect. CRE is deadly in 40 to 50 percent of patients. CRE tops the list of troubling antibiotic resistant (ABR) bacteria that can infect patients, but it's not the only superbug prompt the concern of health experts.12 Diseases That Just Won't Quit
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A colorized scanning depicts a number of E. coli bacteria. According to the CDC, there are 73,000 cases of E. coli infection and 61 deaths occurring in the United States each year.5 Disease Outbreaks Linked to Vaccine-Shy Parents
Above, a radiographer in London reviews an abnormal chest X-ray that suggests active tuberculosis. TB kills more than a million people a year, and multiple strains are becoming drug resistant. Even when treated for multi-drug resistant strains, which can take two years, only about half of patients survive, Dr. Margaret Chan, director general of the World Health Organization,told ABC News
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Drug-resistant gonorrhoeae (
) is considered an "urgent threat" by the CDC. The STD is typically treatable, but a new strain does not respond to available antibiotics.VIDEO: The Plague: Still Here, Still Killing People
SEBASTIAN KAULITZKI/Science Photo Library/Corbis
Bacteria known as MRSA (Methicillin-resistant
) can cause skin diseases and pnuemonia. This strain of staph bacteria is resistant to antibiotics used to treat regular staph infections.Smallpox Vials Found: Could It Strike Again?
Dr. Fred Hossler/Visuals Unlimited/Corbis
(or C. diff) causes severe, infectious diarrhea, typically during or shortly after a course of antibiotics. Cases in the UK and the United States are on the increase, and can result in serious disease and death, according to theNational Institutes of Health
. C. diff infection causes 14,000 deaths in the United States alone.Going Viral: Pandemics in Fiction and Fact
Top public health officials worry that a freakish superbug created on Chinese pig farms may take the world by storm, and there’s not much we can do about it. Scientists now are reporting the emergence of a new method of antibiotic resistance to colistin, one of the last remaining drugs that can still treat most bacterial infections.
In this week’s Lancet, Chinese scientists report the first recorded resistance to colistin in common gut bacteria found in both humans and pigs.
“If it did spread, and we only had the current drugs we have now, it would be a very bad thing,” said Jean Patel, director of Centers for Disease Control’s office of antimicrobial resistance. “These type of bacteria would be very hard to treat.”
Patel and other medical experts take the threat seriously because it has the ability to easily transfer the resistance gene, MCR-1, to other bacteria. The Chinese researchers say the resistant bacteria has been found throughout China, and may have already spread to Malaysia.
In the United States, only a few highly-specialized laboratories have the ability to test for this resistant bacteria, Patel said. The CDC has asked Congress to approve a $264 million package of anti-microbial resistant initiatives including setting up a detection network across the country.
Patel said these types of E.coli bacteria normally live in the human gastrointestinal tract. Healthy people could carry them without getting sick until they spread in hospitals.
“We see transmission in health care institutions,” Patel said. “Someone who might carry it, they usually acquired it in a health are setting. Once treated with antibiotics. They can flourish and take over.”
The resistant bacteria was likely the result of an overuse of colistin in Chinese pig farms, which use the drug to promote growth, according to the authors of the Lancet paper.
China is one of the world’s biggest users of colistin for both livestock and aquaculture, the authors wrote.
“This increasingly heavy use of colistin could have resulted in high selective pressure in the veterinary environment and led to the acquisition of MCR-1 by E coli,” according to the paper. “We anticipate that the amount of colistin used in animal feed is likely to provide survival advantage for MCR-1-producer bacterial populations over colistin-sensitive bacterial populations.”
Mark Woolhouse, professor of infections disease epidemiology at the University of Edinburgh, says the number of weapons left to fight anti-microbial resistance is growing smaller. A new kind of antibiotic, called Teixobactin, was isolated and cultured by researchers in January, but is still several years away from commercial availability.
So too are new gene-editing techniques such as CRISPR Cas-9, which work by carefully snipping out specific genes from a cell or microorganism and leaving it to function normally, or something called phage therapy, which uses a virus to inject its genome into the bacteria and destroy it.
“They are all at the early stages. If we have a new form of resistance which will spread globally in a few years, I’m not optimistic that these will work. Still, we should keep trying.”
Woolhouse believes that developing vaccines for common bacterial infections may be a better route, because they would allow the body’s own natural defenses to keep the person healthy.
In the meantime, the CDC’s Patel says that her agency is ramping up detection efforts for the new Chinese superbug.
“We are going to look for this mechanism of resistance in our surveillance systems to make sure we don’t miss this,” Patel said. “And make sure appropriate prevention strategies are in place.”