Life Hums: Proteins Constantly Vibrate in the Body
Dr. Jan Michels, Christian-Albrechts-Universi
It might sound a bit cramped, but there's an entire world of organisms that can call a drop of water their home. And, up close, they look practically out-of-this-world. Each year, the Nikon Small World competition sets out to collect some of the best microphotography. Take a look at some of this year's most stunning images of creatures that live in water. This photo from Dr. Jan Michels of Christian-Albrechts-Universität zu Kiel in Kiel, Germany shows Temora longicornis, a marine copepod, from its ventral view at 10 times magnification.
SEE MORE PHOTOS: It's a Nikon Small World After All
Frank Fox, Fachhochschule Trier/Nikon Small W
This microphotograph shows the diatom Melosira moniliformis at 320 times its size.
Jonathan Franks, University of Pittsburgh/Nik
This algae biofilm photographed up-close makes what's usually referred to as "pond scum" look like art.
Michael Shribak and Dr. Irina Arkhipova, Mari
This Philodina roseola rotifer was alive and well when this microphotograph was taken.
Dr. Ralf Wagner/Nikon Small World
This microphoto shows a water flea flanked by green algae.
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Charles Krebs Photography/Nikon Small World
Warfare in a water droplet! This microphoto shows a Hydra capturing a water flea at 40-times magnification.
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Dr. John H. Brackenbury, University of Cambri
One of the ultimate human pests -- the mosquito -- begins life as larvae, here shown suspended in a single droplet of water.
Gerd A. Guenther/Nikon Small World
Ever wonder what sex between two freshwater ciliates looks like magnified at 630 times its actual size? Now you know!
Joan Rohl, Institute for Biochemistry and Bio
This freshwater water flea is shown at 100 times its actual size.
Wolfgang Bettighofer/Nikon Small World
Closterium lunula, a kind of green alga, is shown here. This particular specimen came from a bog pond, according to the photographer.
John Gaynes, University of Utah/Nikon Small W
While it may resemble a visitor from outer space, this is what a zebrafish embryo looks like under a microscope, three days after being fertilized.
Dr. Carlos Alberto Muñoz, University of Puer
This microscopic crustacean appears yellowish-orange because it is mounted in Canada Balsam with crystals and other artifacts.
The millions of proteins in humans and other living things vibrate in different patterns like the strings on a violin or the pipes of an organ, according to a new study in Nature Communications.
Scientists have long suspected that proteins vibrate in such a manner, but now they have the high tech means to prove that this really happens.
The research team, from the University at Buffalo and Hauptman-Woodward Medical Research Institute, found that the vibrations persist in molecules like the “ringing of a bell,” lead author and UB physics professor Andrea Markelz said in a press release.
We are not consciously aware of these non-stop vibrations. (Can you imagine what it would be like if we were?) But it’s fascinating to think that a veritable symphony of vibrations plays on in us and in other species.
The tiny motions enable proteins to change shape quickly so they can readily bind to other proteins, a process that is necessary for the body to perform critical biological functions like absorbing oxygen, repairing cells and replicating DNA, Markelz explained.
She added that the research opens the door to a whole new way of studying the basic cellular processes that enable life.
“People have been trying to measure these vibrations in proteins for many, many years, since the 1960s,” Markelz said.
She and her team managed to do it based on an interesting characteristic of proteins. They vibrate at the same frequency as the light they absorb. This is analogous to the way wine glasses tremble and shatter when a singer hits exactly the right note.
“Wine glasses vibrate because they are absorbing the energy of sound waves, and the shape of a glass determines what pitches of sound it can absorb,” she said. “Similarly, proteins with different structures will absorb and vibrate in response to light of different frequencies.”
In order to study vibrations in a protein known as “lysozyme,” the scientists then exposed a sample to light of different frequencies and polarizations, and measured the types of light the protein absorbed. This allowed them to identify which sections of the protein vibrated under normal biological conditions. The researchers were also able to see that the vibrations endured over time, challenging existing assumptions.
“If you tap on a bell, it rings for some time, and with a sound that is specific to the bell,” Markelz said. “This is how the proteins behave. Many scientists have previously thought a protein is more like a wet sponge than a bell: If you tap on a wet sponge, you don’t get any sustained sound.”
She concluded, “The cellular system is just amazing. You can think of a cell as a little machine that does lots of different things — it senses, it makes more of itself, it reads and replicates DNA, and for all of these things to occur, proteins have to vibrate and interact with one another.”
(Image: healthy human T-cell; Credit NIAID/NIH)