Flu Vaccine May Work Better in Women
June 28, 2012 --
Today the Supreme Court upheld the 2010 health care law in a dramatic victory for President Barack Obama. The lead up to today's decision has prompted debate between opponents and supporters of the Patient Protection and Affordable Care Act two years ago. Take a look at how we got to the health care system we have in place today.
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Prior to the 20th century, nothing even close to what could be called a health care system existed in the United States. Although the Civil War had led to some medical breakthroughs in terms of surgical techniques and pain management, medical knowledge, techniques and treatment availability at the time left little hope that patients would actually recover from severe ailments. As NPR's Alex Blumberg and Adam Davidson point out, medical treatments may have been downright medieval at the time, consisting of potions. But at least it was cheap. "In 1900, the average American spent $5 a year on health care ($100 in today's money)," they note in their report.
How the Civil War Changed Modern Medicine
In 1912, Theodore Roosevelt was the first presidential candidate to get behind the idea of a national health insurance plan. Roosevelt ultimately didn't win election that year. Proponents of government-provided health care tried to press the issue through state initiatives, only to see their efforts fail in 16 states. Roosevelt's plan may have certainly been ahead of its time, particularly since there weren't that many services that doctors could actually provide patients during that era.
At the same time, however, developments within the medical community changed the face of the industry. The horrors of World War I led to advances in the areas of wound care, sanitation, pain management and more, according to an article published in the Journal of the Royal Society of Medicine. Hospitals in the United States began to widely adopt the practice of using antiseptics to sanitize their facilities, preventing the possibility of medical personnel or patients becoming exposed to infection. That decade also saw the introduction of the first employer group insurance contracts (though not specifically for health insurance) as well as the first physician service and industrial health plans.
In 1928, Alexander Fleming made one of the most important discoveries in the history of medicine: penicillin, a life-saving drug used to treat countless millions. It would be decades, however, before penicillin would be mass-produced. Fleming's discovery was the signature achievement in an era that saw medical treatment become more effective, and, as a result, expensive. The Great Depression also fueled concerns about affordability of medical treatment as millions of Americans suddenly found themselves out of work. In 1929, Baylor Hospital provided the first group health insurance plan in the United States through an agreement with Dallas-area teachers. The plan was the forerunner of Blue Cross. The effort wasn't just meant to be in the best interests of patients, but also the hospitals. Patient facilities saw more empty beds as fewer patients during the Great Depression could afford treatment without participating in these collective prepaid health insurance plans.
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As part of his push to create a social safety net for Americans during the Great Depression, President Franklin D. Roosevelt advocated the passage of national health insurance. Roosevelt pushed ahead with efforts to pass Social Security first, a bill which intentionally omitted any mention of medical care to ensure its passage. Harry Truman attempted to carry on Roosevelt's legacy in 1945 by calling on Congress to create such a program. His efforts failed, partly due to criticism by the American Medical Association (AMA), who called the plan "socialized medicine." In this photo taken in 1937, First Lady Eleanor Roosevelt examines a chart of enrollment of health care insurance plans.
Like its predecessor, World War II would lead to new medical advancements, including the widespread adoption of antibiotics and the use of ultrasound. The war would also have a similar effect in terms of the spread of employer-sponsored health plans. Because the nation was in a state of emergency and had a legally mandated wage freeze as a result, employers had to attract workers to assist the war effort by providing them with benefits, including health insurance. Tax laws passed between 1943 and 1945 also gave breaks to employers who provided insurance to their employees, which gave businesses all the more incentive to offer coverage. Following the war, employer-sponsored health insurance became common. In 1951, around 77 million Americans had some kind of coverage, according to an insurance industry trade group. That era also saw one of the most celebrated medical achievements in history: Jonas Salk's polio vaccine.
NEWS: World War II
Although health insurance was widely available to employed Americans in the mid-20th century, the unemployed and the elderly were often excluded from these plans. President John F. Kennedy campaigned on the issue of insuring these groups. President Lyndon B. Johnson succeeded where Kennedy left off, securing the passage of a bill through Congress creating Medicare and Medicaid. At the bill-signing ceremony, shown here, Johnson presented former president Truman with the nation's first Medicare card. Within the medical industry itself, an increasing number of doctors began specializing in certain fields of medicine rather than acting as general physicians. By 1960, more than two-thirds of doctors reported themselves as full-time specialists, rather than general practitioners.
Starting with Richard Nixon in 1970, presidents have offered successive plans for covering the nation's uninsured, but they have have stalled for different reasons. In 1974, Nixon put forward a plan to cover all Americans through private insurance, only to have the Watergate scandal force him out of office. An economic crisis prevented Jimmy Carter from pushing forward with a national health plan. Congress late in Reagan's second term attempted to expand Medicare, only to have the law repealed the following year. Bill Clinton had a 1,300-page health care reform bill that was never even taken up for a vote in Congress. Since Nixon's presidency, health care costs have continued to rise, often outpacing inflation. This increase is due to a number of factors, including the increased use of new medical technologies for diagnosis and treatment. The Patient Protection and Affordable Care Act signed by President Barack Obama was intended to cover the 30 million Americans who live without health insurance, according to the bill's authors. It has been the most far-reaching piece of health care legislation since Johnson's signed the legislation creating the Medicare and Medicaid health care programs.
NEWS:Think You'll Live Long? Think Again
Women have a stronger immune response than men when given the flu vaccine, new research shows.
This may mean that vaccinated women are better protected against catching the flu than vaccinated men, although the new study did not look at this directly, the researchers said.
In the study, researchers examined the inflammatory responses of 53 women and 34 men following vaccination with a flu shot.
Scientists found that men had a weaker response, or less inflammation in their bodies, than women after receiving the vaccine, and the response was weakest among some of the men who had the highest testosterone levels.
The finding "reinforces the message that there are major differences between men and women in terms of their immune systems," said study researcher Mark Davis, a professor of microbiology and immunology at the Stanford School of Medicine. "Like many other areas, it hasn't been that well explored."
Davis said the study does not make immediately clear whether men and women have different levels of flu protection after vaccination, but other research suggests they do. [6 Flu Vaccine Myths]
"There is a literature to say women have better responses in general to infectious diseases, including flu," Davis told LiveScience.
The reasons for the difference are not entirely known, but the researchers noted that testosterone suppresses inflammation.
It’s also possible there is a genetic component to people's flu responses, the researchers said. While the mechanism is not entirely clear, the researchers found the vaccine activated certain genes, and this activation predicted who would have the weakest flu shot response.
"There were a set of genes that were activated, or up-regulated, in men, and that showed the difference," said David Furman, a postdoctoral researcher in Davis's lab and first author on the study. "It turns out that those having the highest testosterone levels and the expression of these gene signatures, they do very, very bad" with their immune response to the vaccine.
In their paper, the authors speculated that an evolutionary reason may explain why men would benefit from suppressed immune systems. In evolutionary terms, men may have experienced more trauma than women, so they may have benefitted from a less-active immune system.
"It also turns out that testosterone suppresses inflammation and that inflammation can be a problem in lots of circumstances. It's a necessary part of immunity … but if it gets out of hand, it can kill you," Davis said.
Gender differences in immunity make for an area ripe for study, he said. Health researchers want to know why women have much higher rates of certain immune diseases, and why during pregnancy those diseases may go into remission. Davis said he hopes his study provides some fodder for subsequent research in the area.
In the future, the new study might suggest some means of improving flu shots, perhaps by adding an ingredient to shots given to men, he said.
"There might be a way to disconnect the testosterone suppression to, say, getting better immunity," Davis said.
The study is being published today (Dec. 23) in the journal Proceedings of the National Academy of Sciences.
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