Deadliest Mushroom Is Spreading Worldwide
Michael Marin Self-Poisons in Courtroom
July 3, 2012 --
Shortly after hearing a guilty verdict while on trial for setting fire to his Phoenix mansion in an effort to get out of his mortgage, former Wall Street trader Michael Marin shocked the courtroom by collapsing and dying in a suspected suicide. Video of Marin suggests he swallowed what media reports are speculating to be a poison pill. Within minutes of swallowing the pill, Marin goes into convulsions and later he's pronounced dead. Whatever Marin succumbed to needed little time to take full effect if the video of the courtroom drama does in fact detail the 53-year-old swallowing the poison that killed him. In this slideshow, take a look at some of the most dangerous poisons known to man.
Amatoxins The mushroom in this photo may not seem as terrifying as its nickname would imply. But a single ounce of this "death cap," which unfortunately can resemble its more edible cousins, is enough to kill a human being. Amatoxins, the poison found in this fungus, is what's behind this mushroom's deadly kick. They can severely damage liver and kidneys, and lead to coma, organ failure and more.
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Anthrax Anthrax was a bacteria that was all but off the radar thanks to decades of vaccination and sterilization programs aimed at containing infection rates. Then in 2001, anthrax became headline news when a series of attacks through the United States Postal Service killed five and sickened 17, according to the Federal Bureau of Investigation. Anthrax spores can spread through the air and can infect a person or animal by coming into contact with a wound on the skin, by being inhaled by the host, or by being ingested in the form of tainted meat. Symptoms of anthrax infection depend on the method of exposure, but typically resemble the common flu. Inhaling anthrax is the most dangerous means of exposure and can be fatal up to 90 percent of the time.
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Botulinum Given that there are many poisons that can be lethal in small doses, pinning down the most dangerous can be considered a somewhat objective exercise. But toxicology experts all seem to agree that botulinum toxin, the same stuff that's used in Botox injections to clear up wrinkles, takes the cake. Botulinum, which causes botulism as the name implies, can cause respiratory failure, neurological damage and more at its worst. The bacteria can enter the body through open wounds or by being ingested in food.
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Cyanide If there's one toxin that has almost become a synonym for poison, it's cyanide. Cyanide can come in the form of a crystal or colorless gas that's been described as having a "bitter almond" smell, according to the Centers for Disease Control and prevention. Cyanide also happens to be everywhere: It's naturally occurring in some foods and plants. It's in cigarettes. Cyanide is used to manufacture plastics, develop photographs, remove gold from ore, and of course kill unwanted insects, among other applications. Cyanide exposure can come from inhalation, ingestion or even touch. Poisoning from cyanide can lead to convulsions, respiratory failure and death in extreme cases.
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Mercury As described by the National Institutes of Health, there are three forms of mercury that can be potentially deadly: elemental mercury, inorganic mercury and organic mercury. Elemental mercury, which is what you find in glass thermometers, older dental fillings and florescent light bulbs, is harmless to the touch, but can be fatal if inhaled. Even if the person exposed survives, poisoning can still lead to long-term or even permanent lung and brain damage. Inorganic mercury, which is used to make batteries, can be deadly when ingested, and lead to kidney damage and worse. Organic mercury, found in fish, can be inhaled or ingested, and usually only affects those exposed over the long term, except in rare cases. Symptoms can range from memory loss to blindness to seizures and more.
Ricin Derived from castor beans, ricin is a naturally occurring poison, and humans can be exposed to it in the air, food or water, according to the CDC. Although the symptoms can vary depending on the method of exposure, ricin works by preventing cells from creating proteins they need to survive. Eventually, these cells die off, which can lead to organ failure.
Sarin Unlike all of the other entries on this list so far, Sarin is a synthetic toxin manufactured as a nerve agent. As explained by the CDC, sarin was originally developed as a pesticide, but this odorless, clear gas quickly became a tool for chemical warfare. Sarin can be inhaled or exposure can come through contact with the eyes or skin. The most recent use of sarin gas was in a series of terrorist attacks in 1994 and 1995 in Matsumoto and Tokyo, Japan, respectively, causing 20 deaths and injuring some 1,600 others. Symptoms from sarin gas exposure include blurred vision, convulsions, respiratory failure and more.
Strychnine Derived from the Strychnos nux-vomica tree native to India and southeast Asia, pure strychnine comes in the form of a white, bitter powder that can be deadly when inhaled, injected or ingested. Although commonly used as a pesticide, it has also surfaced in illegal drugs such as heroin and cocaine, according to the CDC. Strychnine poisoning can lead to muscle spasms, respiratory failure and even brain death within 30 minutes of exposure.
Tetrodotoxin Pufferfish may not seem like particularly dastardly animals based on their appearance alone, but they harbor one of the most deadly poisons known to man. Found in the skin, liver, intestines and other organs of the pufferfish, tetrodotoxin can cause paralysis, convulsions, mental impairment and more to anyone who eats this fish, at least when it's been served improperly. Although only a handful of cases are ever reported in the United States, there are as many as 200 cases annually of tetrodotoxin poisoning in Japan, with a 50 percent mortality rate, according to the Food and Drug Administration (FDA).
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It’s big, meaty, looks innocuous, grows near-edible mushrooms and smells delicious, but the name reveals its toxicity: the death cap.
Native to Europe, the death cap is now an invasive species on every continent except Antarctica, Cat Adams, a Harvard graduate student, writes in Slate.
The spores spread “like glitter at a kids’ glitter party,” writes Adams, who is working on a literature review of the mushroom. In the United States, it’s adapted to grow on live oak trees and native pines, and has spread along the East and West Coasts and appears to be moving south into Mexico.
The good news? An ongoing clinical trial may have found an antidote: S. Todd Mitchell of Dominican Hospital in Santa Cruz and colleagues have treated more than 60 patients with a drug derived from milk thistle. The patients who have started the drug on time (within 96 hours of ingesting the mushroom) and who have still had kidney function intact have all survived.
“When administered intravenously, the compound sits on and blocks the receptors that bring amatoxin into the liver, thus corralling the amatoxins into the blood stream so the kidneys can expel them faster,” Adams wrote. “Only a few patients sought treatment later and did not survive.”
Although Mitchell needs more patients before publishing the research, he says there are virtually no downsides to the drug.
“When we present to FDA, it will be a slam dunk for approval,” he told Slate. “The drug has virtually no side effects, it’s very well tolerated, and if used correctly it’s awesomely effective.”
Photo: Amanita phalloides mushrooms, also known as “death caps,” are seen in a wooded area near Bordeaux, southwestern France, in this October 26, 2006, file photo. Credit: Regis Duvignau/Corbis