Tilikum, the whale behind the fatal injury, performs in a show in this photo.Getty Images

A recently released documentary called "Blackfish" intends to show "how nature can get revenge on man when pushed to its limits," according to the film's website. The filmmakers took an in-depth look at orcas following the death of SeaWorld trainer Dawn Brancheau during a live performance in 2010.

Animals held in tanks, pens or cages may be captive, but that doesn't mean they're contained, as was demonstrated in 2010 at SeaWorld. The tragedy wasn't the only time a captive animal turned on its handler.

Killer Whale Injury at SeaWorld Puzzles Experts

Lions may thrill audiences at the circus, but they also occasionally threaten their trainers.Corbis Images

Working with an apex predator that kills even when it's not hunting means taking a risk means no matter how docile the animal appears to be. Lions can be trained, but they can never really be tame.

A staple of circuses, lion tamers dazzle audiences by prodding the big cats to perform. Occasionally, the lions will turn, however. In 2010, two lions turned on their trainer, Oleksie Pinko, during a show performed before a crowd of hundreds in Lviv, Ukraine. Pinko walked away with minor injuries.

PHOTOS: Lions Captured in the Wild by 'BeetleCams'

Sigfried and Roy appear with a white tiger cub years after the performance that would end their show.Getty Images

No matter how many years a performer working with exotic animals, a wild creature can still be unpredictable and aggressive.

Roy Horn, of the duo Siegfried & Roy, worked with tigers most of his life, his passion for almost 40 years. In 2003, however, a 7-year-old white tiger named Montecore brought that career to an end when he mauled Horn, seizing upon Horn's neck before being separated by the show's crew.

Horn survived the attack, as did Montecore, but the show did not.

PHOTOS: Too Cute! White Tiger Cubs

Ligers exhibit characteristics of both lions and tigers, including their propensity toward aggression.Getty Images

Ligers are half-lion, half-tiger. Given their parentage, it should come as no surprise that these animals are deadly, even when their needs are handled by humans.

In 2008, a liger at Safari's Animal Sanctuary in Broken Arrow, Okla., killed a volunteer, 32-year-old Peter Getz. While Getz was feeding the animal, the liger mauled Getz, attacked his neck and torso. Sanctuary personnel were able to separate the liger from Getz, giving Getz a chance to get out of the cage. But the damage had been done.

Bears need an especially skilled trainer to keep these naturally nomadic animals within their confines.Corbis Images

Big cats aren't the only potential killers in captivity. Bears may also turn on their trainers.

In 2008, a trainer bear that was featured in the movie "Semi Pro" attacked and killed 39-year-old Stephan Miller with a single bite to the neck. According ABC News, Miller was the cousin of famed animal trainer Randy Miller, who had previously described the animal as "the best working bear in the business." He also cautioned of the bear's violent potential.

Bears won't just attack humans, but also potentially other animals that are unfortunate enough to be placed alongside this giant predators. In an ugly stunt that played out at the Shanghai Wild Animal Park in China, a bear mauled a monkey to death during a bike riding race, a skill both had been trained to perform. When they crashed, the bear killed the small monkey before trainers could separate them. The park had a history of animal abuse allegations.

Big Foot Mystery Afoot: Bear, Human, or ...?

Travis the chimp met a bloody end after the attack on Charla Nash.Wikimedia Commons

In a gruesome case that shocked a nation with its brutality, a trained chimpanzee named Travis, who had previously made television appearances, mutilated a woman, Charla Nash, in the home of his owners in Stamford, Conn.

The attack wasn't the first time that Travis showed aggression, but it was undoubtedly the most violent. Nash lost her eyes, hands and most of her face in the attack, forced to undergo many rounds of surgery, including a facial reconstructive procedure.

During the attack, Travis was stabbed by one of his owners in an attempt to pry him off Nash. When officers later arrived on the scene, they shot and killed the ape. Lab tests after the attack showed that Travis's owners had given him tea laced with Xanax in an effort to calm him down earlier that day.

PHOTOS: How Santino, the Chimp, Attacks Visitors

An elephant can do a lot of damage, even when it doesn't mean to.Corbis Images

If there's any animal that can unleash serious damage, even when it doesn't mean to, it's the elephant.

The Elephant Sanctuary in Hohenwald, Tenn., saw tragedy in 2006 when a trainer was killed while tending to an elephant named Winkie. Thirty-six-year-old Joanna Burke was examining a swollen eyelid thought to be caused by an insect bite. Winkie abruptly spun around as Burke approached his side, knocking her across the face and chest. He then took one step too many, and crushed Burke who was lying on the ground, killing her instantly.

The death was ruled an accident following an investigation by the Tennessee Wildlife Resources Agency and the Sheriff's Department, and Winkie was allowed to stay at the park.

Top 10 Camera Trap Wildlife Photos

Kangaroos are widely known as animal boxers, so they definitely know how to throw a punch.Corbis Images

A kangaroo certainly isn't nearly as dangerous as some other animals found in the Australian Outback. But kept in captivity, these animals can do damage when rubbed the wrong way.

An 80-year-old man was attacked in 2011 at an exotic animal farm in central Ohio. The 6-foot-tall, 200-pound male attacked during breeding time, when they can be known to be aggressive. The kangaroo was later euthanized by the farm's owners.

PHOTOS: Bad Animal Mothers

When reacting to fear, horses can be aggressive and dangerous.Corbis Images

Horses are large, fast, powerful animals that have lived alongside humans for millennia. Despite our long-standing relationship with them, horses do still turn on their handlers, occasionally with deadly consequences.

One of the more serious equine-related tragedy came in 2010 during an Independence Day celebration. A pair of horses pulling a buggy got spooked during the Heritage Day Parade in eastern Iowa, trampling 23 people, many of them children, and killing one woman.